Sathya (Navdeep), Guru (Abhinay) and Sathyan (Sathyan) are friends. Anjali (Sara Alambra), Meghna (Suja), Radhika (Madhumitha) and Anu (Mallika Kapoor) come in Sathya's life. The complication that arises, the tussle with Bhadri Narayanan (Prakash Raj) form the rest of the movie.

Sathyanathan is a typical middle class man who has just retired. He wants to buy a plot of land in the city and move in with his wife and children - Uppilinathan(Karthik Kumar), Vishwanathan and Sindhu. But his son Uppilinathan - who is a software engineer - has no interest in the house and is keen to leave India for New York, where he has obtained a job. Sathyanathan buys the plot from "World Famous Properties" which is managed by Vijayakumar.

The film tells the story of Chandru, a singer who is touring Singapore with his band where he meets his love interest Sona only to find that she is terminally ill. The movie takes a turn when Chandru finds out about Sona’s cancer and decides to grant her final wish of performing on stage with his band. Ninaithale Inikkum was filmed around various locations in Singapore such as Paya Lebar Airport, Mount Faber, Orchard Towers and the Singapore River.